[Frontiers in Bioscience 3, e149-163, August 6, 1998]
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CAVEAT LECTOR




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RELATIONSHIPS BETWEEN THE STRUCTURE AND THE ROLES OF LIPOARABINOMANNANS AND RELATED GLYCOCONJUGATES IN TUBERCULOSIS PATHOGENESIS

Alain Vercellone, Jérôme Nigou, and Germain Puzo

Institut de Pharmacologie et de Biologie Structurale, UPR 9062, Centre National de la Recherche Scientifique, 205, route de Narbonne, 31077 Toulouse Cedex, France

Received 7/5/98 Accepted 8/3/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. LAM purification
4. LAM structure
4.1. Polysaccharidic core
4.2. Phosphatidyl-myo-inositol anchor
4.2.1. Structural features
4.2.2. Structural determination
4.3. Capping motifs
4.3.1. Structural features
4.3.2. Structural determination
5. Lipoglycans modulate cytokine secretion
5.1. Lipoglycans and TNF-alpha
5.2. Lipoglycans and other cytokines
6. Lipoglycans modulate macrophage effector function
7. Protein receptors of LAM
8. Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Glycobiology, Receptors, Mycobacteria, Lipoarabinomannans, Cytokines

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