[Frontiers in Bioscience 8, a26-33, January 1, 2003]

PHOTOCARCINOGENESIS: MEASURING THE REPRODUCIBILITY OF A BIOLOGIC RESPONSE TO ULTRAVIOLET RADIATION EXPOSURE IN MICE

Christopher P. Sambuco, P. Donald Forbes, Ronald E. Davies, Douglas B. Learn, Luigi C. D'Aloisio, Marvin Arocena, and Alan M. Hoberman

The Center for Photobiology, Argus Research, Charles River Laboratories Discovery and Development Services, Horsham, PA, 19044, USA

FIGURES

Figure 1. A typical emission spectrum for the 6.5 kilowatt xenon long arc lamp with a 1 mm Schott WG 320 doped glass filter.

Figure 2. Average skin tumor prevalence for tumors >1, >2 and >4 mm in planar diameter for mice (sexes combined) exposed to simulated sunlight at 600 RBU/Week for the first forty weeks of each study. Each curve (or cumulative distribution function) represents the mean prevalence of the nine studies reported here.

Figure 3. Average skin tumor prevalence for tumors >1, >2 and >4 mm in planar diameter for mice (sexes combined) exposed to simulated sunlight at 1200 RBU/Week for the first forty weeks of each study. Each curve (or cumulative distribution function) represents the mean prevalence of the nine studies reported here.