[Frontiers in Bioscience 9, 3105-3123, September 1, 2004]

ANGIOGENESIS AND ITS ROLE IN THE BEHAVIOR OF ASTROCYTIC BRAIN TUMORS

Shirley I. Stiver

Beth Israel Deaconess Medical Center, Departments of Surgery and Pathology, Research North, Room 289, 330 Brookline Avenue, Boston, MA 02215

FIGURES

Figure 1. Angiogenic patterns in human glioblastoma multiforme tumors. A) Small delicate vessels (arrows) characterize the vasculature of normal human cortex. B) Prominent vessels in brain parenchyma juxtaposed to a glioblastoma tumor give the appearance of sprouting angiogenesis at the invading tumor front. C) An angiogenic sprouting pattern is further evidenced as an increased density of small vessels within a field of pleomorphic malignant cells. D) Endothelial proliferation, manifested as a garland of vessels with hyperplastic endothelial cells (arrows), is a diagnostic criterion for grade IV glioblastoma tumors. E) Glomeruloid structures are a bizarre form of endothelial proliferation that comprise capillary tufts (arrows) dispersed amidst a proliferation of endothelial cells and pericytes. F) Invasive tumor cells (arrows) of glioblastoma tumors show a predilection for perivascular cuffing. Hematoxylin and eosin stained paraffin sections. Scale bars: 50 m m.