[Frontiers in Bioscience 11, 209-220, January 1, 2006]

Molecularly targeted treatment of chronic myeloid leukemia: beyond the imatinib era

Tariq I Mughal and John M Goldman

Division of Hematology and Oncology, University of Massachusetts Medical School, Worcester, Massachusetts and the Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. BCR-ABL tyrosine kinase
4. Targeting BCR-ABL tyrosine kinase activity
4.1. Current clinical results of BCR-ABL tyrosine kinase inhibition
4.2. Resistance mechanisms to imatinib
4.3. Strategies to overcome the BCR-ABL resistance
4.4. Vaccines
5. Conclusions and future directions

1. ABSTRACT

Chronic myeloid leukemia cells contain a BCR-ABL oncoprotein with an enhanced tyrosine kinase activity, which is considered to be the principal 'cause' of the leukemia. Though the precise mechanisms underlying the leukemogenesis remains enigmatic, the use of imatinib to inhibit the dysregulated kinase activity has proved remarkably successful in clinical practice. Imatinib was the first small molecule developed to inhibit BCR-ABL tyrosine kinase activity and its success introduced the current era of molecularly targeted therapies for a number of other malignancies. In patients with chronic myeloid leukaemia who develop resistance to imatinib, the Bcr-Abl signaling pathway is often re-established. This has led to the emergence of a number of alternative treatment strategies designed to target the leukemic cell which are resistant to imatinib.