[Frontiers in Bioscience 11, 221-231, January 1, 2006]
Role of protein modifications mediated by transglutaminase 2 in human viral diseases
Ju-Hong Jeon and In-Gyu Kim
Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center (AARC), Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110-799, Korea
TABLE OF CONTENTS
Transglutaminase 2 (TG2) belongs to a family of calcium-dependant enzymes that catalyze transamidation reaction, producing polymerized, polyaminated or deamidated proteins. Recently, a growing number of viral proteins as well as cellular proteins with which they interact have been found to be modified by TG2, suggesting a novel function for TG2 in viral pathogenesis. This review summarizes the results of relevant research, examines the mechanisms underlying TG2 function in host-virus interactions and proposes a model for viral pathogenesis involving TG2.