[Frontiers in Bioscience 11, 498-501, January 1, 2006]
Primary gastrointestinal stromal tumor of the liver with lung metastases successfully treated with STI-571 (imatinib mesylate)
Annarosaria De Chiara 1, Vincenzo De Rosa 2, Secondo Lastoria 3, Renato Franco 1, Gerardo Botti 1, Vincenzo Rosario Iaffaioli 4, and Gaetano Apice 4
1U.O.C. Pathology , 2 U.O.C. Radiology, 3 U.O.C. Nuclear Medicine, 4 U.O.C. Medical Oncology B, Istituto dei Tumori di Napoli "G. Pascale", Italy
TABLE OF CONTENTS
We report a case of a primary malignant GIST of the liver metastatic to the lung in a 37 years-old man. The liver tumor showed histological feature of a GIST and expressed vimentin, and diffusely exhibited CD117. One year after the resection of the liver mass, the patient developed multiple small lung metastases which completely disappeared with STI-571 (imatinib mesylate -Gleevec) therapy. C.T. or PET did not show any mass in the abdomen. These findings suggest that the liver mass was a primary rather than a metastatic tumour. They also support the hypothesis that GIST could originate from undifferentiated mesenchymal cells capable to differentiate toward a pacemaker cell phenotype, which are present in sites other than the G.I. tract.