[Frontiers in Bioscience 11, 1216-1226, May 1, 2006]

Using Inbred Mouse Strains to Identify Genes for Complex Diseases

Hooman Allayee 1 Ali Andalibi 2,3, and Margarete Mehrabian 4

1 Department of Preventive Medicine and Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9075, 2 The Gonda Department of Cell and Molecular Biology, 3 Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, 4 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679

TABLE OF CONTENTS

1. Abstract
2. Genetics of Complex Diseases
3. Inbred Mouse Strains
4. The Quantitative Trait Locus Approach
5. From Mouse to Therapy
6. Prospects for the Future
7. Conclusions
8. Acknowledgments
9. References

1. ABSTRACT

In recent years, genetic studies in humans have identified a handful of genes that are associated with common disorders, but our understanding of such diseases at the genetic level remains relatively rudimentary. The use of mice to dissect the complex genetic etiology of common disorders offers a viable alternative to human studies since experimental parameters, such as environmental influences, breeding scheme, and detailed phenotyping can be controlled. This review focuses on the utility of mouse genetics for identification of complex disease genes. Atherosclerosis is used as a representative example, followed by an overview for the prospects of successful gene discovery in the future.