[Frontiers in Bioscience 11, 1814-1817, May 1, 2006]

Apoptosis Gene Information System - AGIS

Kishore R. Sakharkar 1, Marie V. Clement 2, Vincent T.K. Chow 1, and Shazib Pervaiz 3

1 Human Genome Laboratory, Department of Microbiology, 2 Department of Biochemistry, 3 Department of Physiology and Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and Methods
3.1. Dataset creation
3.2. Gene information
3.3. Ortholog mapping and clustering
3.4. Database creation
4. Results and Discussion
4.1. Data integration and AGIS
4.2. Comparative genomics and apoptosis using AGIS
4.3. AGIS interface and availability
4.4. AGIS goal and update
5. Search Example
6. References

1. ABSTRACT

Genes implicated in apoptosis have great relevance to biology, medicine and oncology. Here, we describe a unique resource, Apoptosis Gene Information System (AGIS) that provides data for over 2400 genes involved directly or indirectly, in apoptotic pathways of more than 350 different organisms. The organization of this information system is based on the principle of one-gene, one record. AGIS will be updated on a six monthly basis as new information becomes available. AGIS can be accessed at: http://www.cellfate.org/AGIS/.