[Frontiers in Bioscience 12, 1041-1048, January 1, 2007]
The biological significance of mtNOS modulation
María C. Carreras 1,2, María C. Franco 1, Paola V. Finocchietto 1,3, Daniela P. Converso 1, Valeria G. Antico Arciuch1, Silvia Holod1,2, Jorge G. Peralta1,3 and Juan J. Poderoso 1,3
1Laboratory of Oxygen Metabolism and 2 Departments of Clinical Biochemistry, and 3 Medicine, University Hospital, University of Buenos Aires, Buenos Aires, Argentina
TABLE OF CONTENTS
In the last years, nitric oxide synthases (NOS) have been localized in mitochondria. At this site, NO yield directly regulates the activity of cytochrome oxidase, O(2) uptake and the production of reactive oxygen species. Recent studies showed that translocated neuronal nitric oxide synthase (nNOS) is posttranslationally modified including phosphorylation at Ser 1412 (in mice) and myristoylation in an internal residue. Different studies confirm that modified nNOS alpha is the main modulable isoform in mitochondria. Modulation of mtNOS was observed in different situations, like adaptation to reduced O(2) availability and hypoxia, adaptation to low environmental temperature, and processes linked to life and death by effects on kinases and transcription factors. We present here evidence about the role of mtNOS in the analyzed conditions.