[Frontiers in Bioscience 13, 2495-2503, January 1, 2008]
Role of caspase-independent apoptosis in cardiovascular diseases
Soochan Bae, Bhargavi Yalamarti, Peter M. Kang
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215
TABLE OF CONTENTS
Apoptosis plays an important role in various cardiovascular diseases, and inhibition of cardiac apoptosis shows promise as a therapeutic strategy. Caspase, a critical enzyme in the induction and execution of apoptosis, has been targeted to inhibit apoptosis. However a newly recognized caspase-independent apoptosis pathway may also play an important role in cardiac apoptosis. Yet the mechanism and the potential significance of caspase-independent apoptosis in the heart remain poorly understood. In this paper, we reviewed the literatures on the mechanism of caspase-independent apoptosis and its significance in cardiovascular diseases.