[Frontiers in Bioscience 4862-4872, May 1, 2008]

The role of chemokines during herpes simplex virus-1 infection

Todd R. Wuest1, Daniel J. J. Carr1,2

1Department of Microbiology, Immunology, and 2 Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK


1. Abstract
2. Introduction
3. Chemokine Signaling
4. Chemokine Production During HSV-1 Infection
5. Chemokines and Leukocyte Recruitment at Sites of Early Viral Replication
6. Chemokines in the Sensory Ganglia and Central Nervous System
7. Chemokines and the Generation of the Adaptive Immune Response
8. T-cell Homing to Neural Tissues
9. Chemokines and HSV-1 Latency
10. Perspective
11. Acknowledgements
12. References


Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.