[Frontiers in Bioscience 4862-4872, May 1, 2008]
The role of chemokines during herpes simplex virus-1 infection
Todd R. Wuest1, Daniel J. J. Carr1,2
1Department of Microbiology, Immunology, and 2 Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
TABLE OF CONTENTS
Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.