[Frontiers in Bioscience 14, 1589-1595, January 1, 2009]

[Frontiers in Bioscience 14, 1589-1595, January 1, 2009]

Activation of dendritic cells by polymorphonuclear neutrophils

Unite Mixte de Recherche 7151 Centre National de la Recherche Scientifique, Universite Denis Diderot Paris 7, Institut Universitaire d'Hematologie, Hopital Saint-Louis, Paris, France

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion: 3.1. Accession of DCs to the antigen presenting cell status; 3.2. Neutrophils as regulator cells of the adaptive immune response; 3.3. Neutrophils attract DCs; 3.4. Activated neutrophils deliver both activation signals and antigen to DCs; 3.5. Molecular mechanisms of neutrophil-DC communication; 3.6. Do dying neutrophils regulate DC activation?; 3.7. Conclusion 4. Acknowledgement
5. References

1. ABSTRACT

The obsolete view describing neutrophils as innate immune cells that respond rapidly to microbial invasion and then rapidly die by apoptosis is now challenged by several data. In both human and mice, there are now evidences that neutrophils play a role in dendritic cell activation, a critical step for the outcome of the specific T cell response.