[Frontiers in Bioscience 14, 3074-3084, January 1, 2009]

Microbial functionality in the human intestinal tract

Anne Salonen1, Airi Palva1, Willem M. de Vos1,2

1Department of Basic Veterinary Medicine, Division of Microbiology and Epidemiology, University of Helsinki, P.O. Box 66, FI-00014, Helsinki, Finland, 2Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Metabolic impact of GI microbiota
4. Effect of diet on GI microbiota
5. From diversity to functional genomics 5.1. Transcriptomics
5.2. Proteomics
5.3. Metabolomics
6. Summary and perspective
7. References

1. ABSTRACT

The extent of metabolic interactions between symbiotic intestinal microbes and the human host, and their system-wide effects on the host physiology are beginning to be understood. The metabolic capacity encoded by the intestinal microbiome significantly extends that of the host, making many of man's physiological characteristics an outcome of a human-microbe co-metabolism. A detailed characterization of the composition and function of the gut microbial ecosystem is required to foster the understanding of its mechanisms and impact. The most recent research on the intestinal ecosystem is reviewed here, with specific attention to the ecological aspects including the anticipated effects of probiotics and prebiotics. Finally, the post-genomics approaches that advance discovering the functionality of intestinal bacteria are addressed.