[Frontiers in Bioscience 14, 3892-3898, January 1, 2009]

Preventing and treating chronic disorders using the modified vaccination technique

Arpad Zsigmond Barabas1, Donald Mackay Weir2, Chad Douglas Cole3, Arpad David Barabas1, Nizar Jacques Bahlis4, Richard Milton Graeff5, Rene Lafreniere1

1Department of Surgery, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada, 2University of Edinburgh Medical School, Scotland,3Department of Neurosurgery, University of Utah, Salt Lake City, Utah, USA, 4Department of Medicine/Oncology, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada, 5Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Background to autoimmunity
4. The beneficial aspects of immune complexes in initiating and maintaining predetermined immune response outcomes
4.1. The biologics needed to make up the relevant immune complexes to combat human chronic disorders
4.1.1. To prevent or treat/terminate autoimmune diseases
4.1.2. To prevent or treat/terminate cancer
4.1.3. To prevent or treat/terminate presently incurable chronic diseases
5. Perspectives
6. Acknowledgement
7. References

1. ABSTRACT

It is anticipated that the ultimate solution for the prevention and termination of autoimmune disorders will be based on somehow manipulating the cells of the immune system to attain antigen (ag) specific downregulation and termination. In the last few years we have developed a new vaccination technique that we call "modified vaccination technique" (MVT). It has with equal effectiveness both prevented and terminated autoimmune disease causing events in an experimental autoimmune kidney disease model. We expect that our technique will be similarly applicable to the specific treatment and cure of numerous other chronic disorders presently treated only by drugs. The vaccine is composed of two components, an ag and a specific antibody against it. When these are combined at slight ag excess they constitute a vaccine which is capable of treating chronic ailments by redirecting immune response outcomes in the vaccinated host. Both components, like drugs, will have to be produced ex vivo in order to maintain uniformity, safety, efficacy, and specificity.