[Frontiers in Bioscience 14, 4113-4126, January 1, 2009]

Cooperative production of siderophores by Pseudomonas aeruginosa

Freya Harrison1,2, Angus Buckling1

1Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS UK, 2Current address: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY UK

TABLE OF CONTENTS

1. Abstract
2. Introduction: siderophores are a 'public good.'
3. Siderophore cooperation and virulence
4. Testing Hamilton's rule using siderophores: the importance of population structure
5. The influence of the abiotic and biotic environment on siderophore cooperation
6. Hypermutability and cooperation
7. Links between siderophore production and biofilm formation
8. Conclusions and suggestions for future work
9. Acknowledgements
10. References

1. ABSTRACT

The production of iron-scavenging siderophores by the opportunistic animal pathogen Pseudomonas aeruginosa is a textbook example of public goods cooperation. This trait provides an excellent model system with which to study cooperation. Further, the links between siderophore production and P. aeruginosa virulence allow us to investigate how pathogen ecology, social behaviour and pathology might be connected. We present here the results of basic research on the evolution and ecology of siderophore cooperation in this species. In particular, we explore the effects of population and community structure, iron regime and genomic mutation rate on the relative success of siderophore cooperators and cheats. We also present preliminary data on the links between siderophore production and another clinically-relevant social trait, biofilm formation. It is our hope that more realistic laboratory studies of siderophore cooperation in P. aeruginosa will eventually cast light on the roles played by social traits in long-term microbial infections.