Human genetics of diabetes mellitus in Taiwan
Pei-Lung Chen1,2, Wei-Shiung Yang1,3,4
1
Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 2Program in Human Genetics, Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA, 3Graduate Institute of Clinical Medicine, 4Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
TABLE OF CONTENTS
- 1. Abstract
dt>2. Introduction
- 3. Genetics of type 1 DM 3.1. Summary of the current progress of type 1 DM genetics
- 3.2. Review of type 1 DM genetics in Taiwan 4. Genetics of type 2 DM 4.1. Summary of the current progress of type 2 DM genetics
- 4.2. Review of type 2 DM genetics in Taiwan 5. Genetics of mitochondrial diabetes
- 5.1. Summary of the current progress of mitochondrial DM genetics
- 5.2. Review of mitochondrial DM genetics in Taiwan 6. Genetics of MODY and genetic syndromes 6.1. Summary of the current progress of MODY genetics
- 6.2. Review of MODY genetics in Taiwan
- 6.3. Summary of the current progress of genetic syndrome of DM
- 6.4. Review of genetic syndrome of DM in Taiwan 7. Perspectives
- 8. Acknowledgements
- 9. References
1. ABSTRACT
Diabetes mellitus (DM) is a disease defined by biochemical hyperglycemia. Currently it is classified into four major categories: type 1 DM (T1DM), type 2 DM (T2DM), gestational DM (GDM) and other DM. Within each category, the etiology is still heterogeneous. The pathogenesis of most DM is multi-factorial, including many genetic and environmental factors. T1DM, T2DM and GDM are polygenic. In the category of other DM, there are at least six maturity onset diabetes of the young (MODY) and many other genetic syndromes associated with DM, which are monogenic in origin. In this review, we briefly summarized the current status of genetics in DM, described what has been done in this specific area in Taiwan and discuss what should be done after the era of genome-wide association study.
