Growth factors in tumor microenvironment

Xuejing Zhang, Daotai Nie, Subhas Chakrabarty

SimmonCooper Cancer Institute, Southern Illinois University School of Medicine

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. Epidermal Growth Factor and Receptor in Tumor Microenvironment

3.1. Epidermal growth factor and epidermal growth factor receptor

3.2. Tumor hypoxia and translational up-regulation of epidermal growth factor receptor

3.2.1. The hypoxic tumor microenvironment triggers the expression of epidermal growth factor receptor

3.2.2. The role of epidermal growth factor receptor in hypoxia-mediated tumor progression

3.3. Role of epidermal growth factor receptor in the Pathogenesis of Metastasis

3.3.1. The direct role of epidermal growth factor receptor in stimulating osteoclast

3.3.2. Epidermal growth factor receptor in mesenchymal stem cell-mediated osteoclast differentiation

3.4. EGFR signaling regulated by tumor microenvironment

4. Fibroblast Growth Factor amd Receptor in Tumor Microenvironment

4.1. Fibroblast growth factor and fibroblast growth factor receptor

4.2. Fibroblast growth factor-mediated stromal-epithelial cross-talk in prostate tumors

4.3. Role of fibroblast growth factor in angiogenesis

4.3.1. Angiogenic synergism between fibroblast growth factor-2 and platelet derived growth factor-BB

4.3.2. Angiogenic synergism between fibroblast growth factor-2 and vascular endothelial growth factor

4.3.3. Clinical anti- angiogenesis target

5. Platelet-Derived Growth Factor and Receptor in Tumor Microenvironment

5.1. Platelet-derived growth factor and platelet-derived growth factor receptor

5.2. Role of platelet-derived growth factorin pancreatic tumor stroma

5.3. Role of platelet-derived growth factor in cervical carcinoma

5.4. Platelet-derived growth factorin tumor cell induced 'stromal resistance

6. Perspective

7. Acknowledgment

8. References

1. ABSTRACT