[Frontiers in Bioscience E2, 733-738, January 1, 2010]

Italy-Japan agreement and discrepancies in diagnosis of superficial gastric lesions

Carla Vindigni1, Mario Marini2, Gabriele Cevenini3, Maria Raffaella Ambrosio4, Monica Onorati5, Giorgio Frosini6, Takuji Gotoda7, Hirokazu Taniguchi8, Piero Tosi9

1Department of Human Pathology and Oncology, Division of Pathological Anatomy and Histopathology, University of Siena, Italy, 2Gastroenterology and Gastrointestinal Endoscopy Unit, University Hospital, Siena, 3Surgery and Bioengineering Department, University of Siena, 4Department of Human Pathology and Oncology, Division of Pathological Anatomy and Histopathology, University of Siena, 5Department of Human Pathology and Oncology, Division of Pathological Anatomy and Histopathology, University of Siena, 6Gastroenterology and Gastrointestinal Endoscopy Unit, University Hospital, Siena, 7Gastrointestinal Endoscopy Unit, National Cancer Center Hospital, Tokyo, Japan 8Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, 9Department of Human Pathology and Oncology, Division of Pathological Anatomy and Histopathology, University of Siena

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and methods
3.1. Endoscopy
3.2. Histopathology
3.3. Statistics
4. Results and discussion
4.1. Results
4.2. Discussion
5. Conclusions
6. References

1. ABSTRACT

The agreement between Italian and Japanese endoscopists and pathologists on endoscopic and histopathological diagnoses of superficial gastric lesions is verified with the use of Paris and Vienna classifications. The correlations between Paris endoscopic types and Vienna histopathological categories is high in both the independent Italian and Japanese evaluations. However, the agreement between Italian and Japanese endoscopists is moderate due to the difficult evaluation of the height of the lesions, in particular when they are mixed. The agreement on the size of the lesions is fairly good. The probability of the same allocation to the Vienna categories of a single case is 87%, disagreements remaining in dysplasia grading, between dysplasia, not only high-grade but also low-grade, and in situ carcinoma, and on cancer invasion of the lamina propria. The results indicate that use of the Paris and Vienna classifications has reduced the discrepancies between Western and Japanese endoscopists and pathologists in the diagnosis of these lesions.