Biomarkers of corticosteroid-induced hypertrophic cardiomyopathy in preterm babies
Pier Paolo Bassareo1, Raul Abella2, Vassilios Fanos3, Giuseppe Mercuro1
1
Department of Cardiovascular and Neurological Sciences, University of Cagliari, Cagliari, Italy, 2Research Laboratory Department of Cardiac Surgery San Donato Milanese University, San Donato, Italy,3Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3.Corticosteroids in neonatal intensive care
- 3.1. Corticosteroids and chronic lung disease in preterm newborns
- 3.3. Morphological and microscopic characteristics of corticosteroids-induced hypertrophic cardiomyopathy
- 3.4. Biomarkers associated with corticosteroids-induced hypertrophic cardiomyopathy
- 3.5. Search strategy
- 3.6. Hormones
- 3.7. Growth factors
- 3.8. Apoptotic biomarkers
- 3.9. Myonecrosis markers: troponin
- 3.10. Markers of endothelial function
- 3.11. Platelet function and prothrombotic markers
- 3.12. Inflammatory biomarkers
- 3.13. Wall stress markers: natriuretic peptide
- 3.14. Matrix metalloproteinases
- 3.15. A proposed pathophysiological model linking biomarkers in corticosteroid-induced hypertrophic cardiomyopathy
- 4. Summary and perspective
- 5. Acknowledgments
- 6. References
1. ABSTRACT
The study of biomarkers and their signaling pathways has led to the development of new therapeutic strategies in a number of disorders. The purpose of the present systematic review is to provide an overview of different biomarkers in preterm newborns with corticosteroid-induced hypertrophic cardiomyopathy (CCHC). Several pathophysiological biomarkers are presented and discussed with the aim of investigating their diagnostic and prognostic value, particularly in relation to the potential progression of the disease and/or mortality in adulthood. This investigative approach may not only provide pathophysiological information on this serious drug-induced adverse effect, but also suggest novel therapeutic approaches to be applied in controlling its harmful consequences.
