[Frontiers in Bioscience E2, 105-110, January 1, 2010]

[Frontiers in Bioscience E2, 105-110, January 1, 2010]

Biochemical characteristics and risk factors in non-alcoholic fatty liver

Ying Wang¹, Jin Dong¹, Hong-ying Liu¹, De-qing Wang¹, Ya-ping Tian¹

¹Department of Clinical Biochemistry, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing, China, 100853

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and methods: 3.1. Demographics of the study population; 3.2. Clinical and biochemical assessments; 3.3. Diagnostic criteria; 3.4. Statistical analysis
4. Results: 4.1. General profile of the study population; 4.2. Characteristics of lipid metabolism; 4.3. Characteristics of glucose metabolism; 4.4. Characteristics of liver function; 4.5. Risk factors for NAFLD
5. Discussion
6. References

1. ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1%. Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. Subjects with NAFLD were obese, hypertensive and often had signs of disturbances in lipid and glucose metabolism and abnormalities in hepatic functions. These findings show risk factors in the development and offer opportunities for prevention of NAFLD.