[Frontiers in Bioscience 16, 2161-2171, June 1, 2011]

The role of miRNAs in cytokine signaling

Claire E. McCoy

Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia


1. Abstract
2. Introduction
3. Cytokine regulation of miRNA
3.1. Interleukin-1
3.2. Tumor necrosis factor
3.3. Interleukin-6
3.4. Interleukin-10
3.5. Interferons
3.6. Transforming growth factor beta
4. Implications in disease
5. Perspectives
6. Acknowledgments
7. References


This review explores the relationship between cytokines and microRNAs (miRNAs). In particular, the regulation of miRNAs by pro-inflammatory cytokines, anti-inflammatory cytokines, interferons and transforming growth factor beta are examined, highlighting how miRNAs can mediate some of the known functions of these cytokines, as well as identifying novel gene targets, mechanisms and cross-talk between pathways.