Significance of membrane microparticles in solid graft and cellular transplantation
Babe Bakouboula1,2,3, Olivier Morel1,2,3, Anne-Laure Faller2,4, Jean-Marie Freyssinet2,3,5, Florence Toti2,3,5
1Hopitaux Universitaires de Strasbourg, Pole de Cardiologie et de chirurgie cardiovasculaire, Strasbourg, France, 2Universite de Strasbourg, Faculte de Medecine, Institut d'Hematologie et d'Immunologie, Strasbourg, France,3INSERM, U.770, Le Kremlin-Bicetre, France, 4Hopitaux Universitaires de Strasbourg, Pole de Nephrologie, Strasbourg, France, 5Universite Paris-Sud 11, Faculte de Medecine, Le Kremlin-Bicetre, France
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Biogenesis and biology of microparticles
- 3.1. Microparticle generation
- 3.2. Composition of microparticles and functionnal characteristics
- 3.3. Cellular origin of membrane microparticles and pathophysiologic background
- 3.4. Clearance of microparticles
- 3.5. Detection and measurement of microparticles
- 3.6. Paradoxical cytoprotective effects of microparticles
- 3.7. Other beneficial effects of microparticles in the maintenance of vascular integrity and function
- 4. Microparticles in transplantation
- 4.1. Kidney transplantation
- 4.2. Heart transplantation
- 4.3. Liver transplantation
- 4.4. Pancreatic islet transplantation
- 4.5. Hematopoietic stem cells transplantation
- 4.6. Pharmalogical and immunosuppresive treatments
- 5. Conclusion
- 6. Acknowledgments
- 7. References
ABSTRACT
Microparticles (MPs) are submicron vesicles released from stimulated or apoptotic cells after plasma membrane remodeling. In body fluids, they constitute relevant hallmarks of cell damage. Having long been considered inert debris reflecting cellular activation or damage, MPs are now considered as cellular effectors involved in cell-cell crosstalk. This review focuses on the pathophysiologic significance of MPs in the particular setting of solid graft and cellular transplantation.
