[Frontiers in Bioscience E3, 864-870, June 1, 2011]

Suppressing allergic immune responses

Hua Huang

Department of Medicine and Integrated Department of Immunology, National Jewish Health, University of Colorado Denver School of Medicine, 1400 Jackson Street, K613e, Denver, CO 80206

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Allergic inflammation
4. The IFN-g-STAT1-IRF or the IFN-g-STAT-T-bet pathway in suppressing Il4 gene transcription
5. The role of T regulatory cells and IL-10 in suppressing Th2 differentiation
6. IL-27-mediated suppression of Th2 differentiation
7. The role of chromatin structure in suppressing Th2 cytokine gene expression
8. Can the knowledge gained be used to improve immunotherapy?
9. Acknowledgements
10. References

1. ABSTRACT

While most studies are devoted to understanding the activation of cytokine gene transcription, few studies have focused on the silencing of cytokine gene transcription. This review will focus on the molecular mechanisms by which Th1-promoting factors downregulate the Il4 gene.