[Frontiers in Bioscience S3, 1058-1066, June 1, 2011]

The function of histamine receptor H4R in the brain revealed by interaction partners

Aurelio A. Moya-Garcia, Carlos E. Rodriguez, Ian Morilla, Francisca Sanchez-Jimenez, Juan A.G. Ranea

Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, and CIBER de Enfermedades Raras (CIBERER), Valencia, Spain

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Methods
3.1. The Knowledgegram and the Predictogram
3.2. Mapping functions on networks
4. Results
4.1. Lack of knowledge about H4R relationships
4.2. H3R and H4R predicted functional associations
4.3. H3R and H4R interactors in the human brain
5. Discussion
5.1. Concluding remarks
6.Acknowledgements
7. References

1. ABSTRACT

The histamine H4 receptor is mainly expressed in haematopoietic cells, hence is linked to inflammatory and immune system conditions. It has been recently discovered that the receptor is expressed also in the mammalian central nervous system (CNS), but its role in the brain remains unclear. We address the potential functions of the histamine H4 receptor in the human brain using a 'guilty by association' logic, by close examination of protein-protein functional associations networks in the human proteome.