[Frontiers in Bioscience 14, 2009-2009, January 1, 2009]

Alternatively spliced tissue factor pathway inhibitor: Functional Implications

Alan E. Mast1

1Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Alternatively spliced forms of TFPI
4. Evolution of alternatively spliced forms of TFPI
5. Tissue expression of alternatively spliced forms of TFPI
6. Perspective: Potential for differential function of alternatively spliced forms of TFPI
7. References

1. ABSTRACT

Tissue factor pathway inhibitor (TFPI) is a factor Xa dependent inhibitor of tissue factor initiated blood coagulation. In recent years several alternatively spliced forms of TFPI have been identified. These alternatively spliced forms have different C-terminal regions and have different mechanisms for association with cell surfaces. They are differentially expressed in human and mouse tissues and may have distinct physiological functions.