[Frontiers in Bioscience 17, 970-975, January 1, 2012]

Function of the INO80 chromatin remodeling complex in DNA replication

Karina B. Falbo1, Xuetong Shen1

1Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, Texas 78957, USA


1. Abstract
2. Introduction
3. A novel role for INO80 during DNA replication
3.1. INO80 is involved in DNA replication
3.2. INO80 and the checkpoint response
3.3. A novel role for INO80 in the DNA damage tolerance pathway
3.4. INO80 is necessary for PCNA ubiquitination and Rad18rRecruitment to replication forks
3.5. INO80 is necessary for Rad51 recruitment to replication forks and its recombination mediated activities
4. Conclusion
5. Future perspective
6. References


ATP-dependent chromatin remodeling complexes are involved in several nuclear processes. In particular the INO80 remodeling complex is an essential factor during transcription and DNA repair. Recently, several labs have described a novel role for INO80 during DNA replication. Moreover, Falbo et al. have presented evidence linking INO80's activities to the DNA damage tolerance pathways during replication (1). In this review we will discuss and integrate the results obtain by these various research groups to describe a novel role for INO80 in DNA replication.