[Frontiers in Bioscience 17, 2391-2395, June 1, 2012]

Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells

Ying Li1, Li-Juan Zhao1, Fang-Zhen Xia1, Yan-Xiang Li1, Ying-li Lu1

1Institute and Department of Endocrinology and Metabolism of Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine

TABLE OF CONTENTS

1. Abstract
2. Introduction to prospects of hepatic oval cells in the treatment of diabetes
3. Hepatic oval cells in beta-cell neogenesis
4. Factors in hepatic oval cell differentiate into isletb cells
4.1. High glucose promotes hepatic oval cell differentiate into islet b cells
4.2. Extracellular matri matrigel induces hepatic oval cell to differentiate into islet b cells
4.3. Cytokine activin a involves into differentiation of hepatic oval cell into islet b cells in pancrease
4.4. Differentiation-related transcription factors in the differentiation of hepatic oval cell into islet b cells in pancrease
4.4.1. Pdx-1
4.4.2. Ngn3
4.4.3. Mafa
5. Conclusion
6. Acknowledgements
7. References

1. ABSTRACT

Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcription factors (Pdx-1, Ngn-3, MafA). We review the process of hepatic oval cell transdifferentiation into pancreatic islet beta-cells and the cellular signaling pathways involved.