[Frontiers in Bioscience 17, 2675-2683, June 1, 2012]
Abnormal bone metabolism in Crohn's disease
Tao Wu1,2, Haiyan Song1, Guang Ji1
1Institute of Digestive Disease, Longhua Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China, 2Center of Chinese medicine therapy and systems biology, shanghai university of Traditional Chinese Medicine, Shanghai 201203, China
TABLE OF CONTENTS
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and population. These diseases result from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This paper reviews the abnormal bone metabolism associated with CD, in order to elucidate the mechanism of bone loss.