[Frontiers in Bioscience E4, 342-350, January 1, 2012]

Trophinin in cell adhesion and signal transduction

Michiko N. Fukuda1, Kazuhiro Sugihara2

1Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA, 2Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan


1. Abstract
2. Introduction
3. Structure and function of trophinin
4. Trophinin-interacting proteins
5. Signals triggered by trophinin
6. Trophinin, bystin and tastin in human cancer
7. Perspectives
8. References


The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells during human embryo implantation and events related to human sperm tail motility. We also report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others.