[Frontiers in Bioscience E4, 480-486, January 1, 2012]

Activation of Wnt and Myc signaling in hepatoblastoma

Stefano Cairo1, Carolina Armengol2, Marie Annick Buendia3

1XenTech, 4 rue Pierre Fontaine, 91000 Evry, France, 2Health Sciences Research Institute, Germans Trias i Pujol Foundation, CIBERehd, Hepatology Unit, C/ Cami de les escoles, s/n, 08916 Badalona, Barcelona, Spain, 3Institut Pasteur, Oncogenesis and Molecular Virology Unit, Virology Department, Inserm U579, 28 rue du Dr Roux, 75015 Paris, France

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Mutational activation of b-catenin in liver cancer
4. Molecular classification of hepatoblastoma and activation of myc signaling
5. Potential therapeutic targets in HB
6. Acknowledgements
7. References

1. ABSTRACT

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. This tumor is thought to derive from hepatic progenitor cells that are arrested at various stages of liver development, as illustrated by a variety of histologic subtypes. Recent genomic studies have led to better understand the molecular pathogenesis of HB, to point out the crucial roles of the Wnt Myc signaling pathways in malignant transformation of liver progenitor cells. Molecular classification of HB based on genome-wide studies, as well as identification of reliable diagnostic prognostic markers, open the way to the development of new personalized targeted therapies for the management of aggressive lethal childhood tumors.