[Frontiers in Bioscience E4, 1150-1156, January 1, 2012]

[Frontiers in Bioscience E4, 1150-1156, January 1, 2012]

Towards three-dimensional structural analysis of (pro)renin receptor

Akio Ebihara¹, Tsutomu Nakagawa¹, Chiaki Nakane², Nurun A.H.M. Nabi¹, Fumiaki Suzuki^1,2

1Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan, ²Graduate School of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Amino acid sequence
4. Receptor binding
5. Structure prediction
6. Towards three-dimensional structural analysis
7. Conclusion
8. Acknowledgements
9. References

1. ABSTRACT

The (pro)renin receptor is a single-spanning membrane protein that binds both renin and its inactive precursor prorenin. The receptor binding enhances the catalytic activity of renin and induces non-proteolytic activation of prorenin as well as triggers intracellular signaling with either renin or prorenin as a ligand. Three-dimensional structural information of (pro)renin receptor is important to understand the receptor binding. This information is not available due to the lack of its three-dimensional structure. In this review, we summarize the binding properties of (pro)renin receptor, provide the results of structure prediction and point out the issues to be tackled towards three-dimensional structural analysis of this receptor.