[Frontiers in Bioscience E4, 1335-1344, January 1, 2012]

Oxidative stress and inflammatory bowel disease

Hazem A. Almenier1, Hazem H. Al Menshawy2, Maha M. Maher3, Salah Al Gamal4

1Mansoura Emergency Hospital, Mansoura, Egypt, 2Medical Specialized Hospital, Mansoura University,35516, Mansoura, Egypt, 3Medical Specialized Hospital, Mansoura University,35516, Mansoura, Egypt, 4Medical Specialized Hospital, Mansoura University,35516,Mansoura, Egypt


1. Abstract
2. Introduction
3. Pathogenesis of Inflammatory Bowel Disease
3.1. Genetics
3.2. Immunopathogenesis
3.3. Familial
3.4. Environmental factors
3.5. Nutritional factors
3.6. Microbial Factors
3.7. Evidence for barrier dysfunction
3.8. Smoking
3.9. Stress
4. Free Radicals
4.1. Evidences of oxidative injury in inflammatory bowel disease (IBD)
4.2. Mechanisms of free radicals Production and Tissue Injury in IBD
4.3. Physiological consequences of uncontrolled oxidant and free radical production in IBD
4.4. Estimating free radical production in IBD
4.5. Molecular genetic alterations in IBD
5. Summery
6. References


Inflammatory Bowel Disease (IBD) is a chronic relapsing and remitting inflammatory condition of the gastrointestinal tract. The exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors. While many gaps in our knowledge still exist, the last two decades have witnessed an unprecedented progress not only in the etiology ; but mainly in the mechanisms underlying the chronic inflammatory response, immunologic and genetic aspects. We review some recent points of research in pathogenesis with special stress on oxidative stress and its correlations with disease activity.