[Frontiers in Bioscience E4, 2029-2044, January 1, 2012]

Medicinal chemistry and nanomedicine for reproductive cancer therapeutics

Debatosh Majumdar1, Sunil Singhal2

1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA, 2Division of Thoracic Surgery, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Nanotechnology
4. Cancer therapeutics in reproductive medicine
5. Nanomedicine in reproductive cancer therapeutics
5.1. Paclitaxel
5.2. Docetaxel
5.3. Doxorubicin
5.4. Cisplatin
5.5. Tamoxifen
5.6. Gemcitabin
5.7. Etoposide
5.8. Anastrazole
5.9. Triptorelin
6. Limitations
7. Conclusions
8. Acknowledgement
9. References

1. ABSTRACT

Nanomedicine is an interdisciplinary research field where chemistry, physics, biology, engineering, nanotechnology, and medicine meet one other. Many novel nanoparticles have been designed, synthesized, and evaluated for selective targeting of cancer cells, delivering, and releasing the anticancer drugs in a controlled manner. In this review article we discuss the current status and future prospects of medicinal chemistry of nanomedicine with particular attention to nanoparticle systems that are in various stages of development for cancer therapy in reproductive medicine.