[Frontiers in Bioscience E4, 2322-2327, June 1, 2012]

[Frontiers in Bioscience E4, 2322-2327, June 1, 2012]

High sensitive troponin T in individuals with chest pain of presumed ischemic origin

Giovanni Cuda¹, Margherita Lentini¹, Luigia Gallo¹, Fortunata G. Lucia¹, Lorenzina Giaquinto Carinci¹, Serafina Mancuso¹, Rosa A. Biondi¹, Raffaella Sinopoli¹, Rita Casadonte¹, Pietro H. Guzzi², Mario Cannataro², Annalisa Mongiardo³, Claudio Iaconetti³, Angela Bochicchio³, Antonio Curcio³, Daniele Torella³, Pietroantonio Ricci⁴, Ciro Indolfi³, Francesco Costanzo¹

1Laboratory of Clinical Biochemistry and Molecular Biology, Fondazione, T. Campanella, University of Magna Graecia, Catanzaro, Italy, ²Laboratory of Bioinformatics, University of Magna Graecia, Catanzaro, Italy, ³Division of Cardiology, University of Magna Graecia, Catanzaro, Italy, ⁴Division of Forensic Medicine, University of Magna Graecia, Catanzaro, Italy

TABLE OF CONTENTS

1. Abstract
2. Introduction
3.Materials and methods: 3.1. Patients population; 3.2. Specimen collection and measurement of cardiac troponin T; 3.3. Statistical analysis
4.Results
5.Discussion
6. References

1. ABSTRACT

This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2 percent vs. 64.3 percent patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the std-cTnT assay, respectively); ii) showing a better time-dependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hs-cTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.