Role of p14^ARF alterations in endometrial tumorigenesis: a mini-review

Andrzej Semczuk¹, Klaudiusz Cieplinski², Atanas Ignatov³, Piotr Olcha¹, Tomasz Rechberger¹

12^ndDepartment of Gynecology, Lublin Medical University, Lublin, Poland, ²Department of Obstetrics and Gynecology, Municipal Hospital in Plock, Plock, Poland, ³Department of Obstetrics and Gynecology, Otto-von-Guericke University, Magdeburg, Germany

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. p14ARF alterations in endometrial carcinogenesis

4. p14ARF immunostaining in normal, precancerous and cancerous human endometrial tissues

5. p14ARF and patients outcome

6. Future perspectives

7. Acknowledgments

8. References

1. ABSTRACT

In the current mini-review, we present a short overview of genetic as well as immunohistochemical p14^ARF alterations either in primary human endometrial carcinomas (ECs) or in metastatic lesions originated from malignant endometrium. The prognostic utility of p14^ARF in uterine malignancies has also been briefly discussed.