Patrick A. Lester^1,2, Jose A. Diaz², Katherine A. Shuster^1,2, Peter K. Henke², Thomas W. Wakefield², Daniel D. Myers^{1, 2}

1Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI, ²Jobst Vascular Research Laboratories, Section of Vascular Surgery,University of Michigan Medical Center, Ann Arbor, MI

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. The epidemiology of vascular thrombosis

4. Adhesion Molecules, Inflammation, and Thrombosis

4.1. Selectins

4.2. P-selectin inhibitors

4.3. Plasminogen activator inhibitor-1 (PAI-1)

4.4. Von Willebrand factor

5. Mediators of inflammation

6. Tissue factor

7. Microparticles and thrombogenesis

8. Inflammation and arterial thrombosis

9. Inflammation and venous thrombosis

9.1. Neutrophil extracellular traps (NETs)

10. Biomarkers for deep venous thrombosis

11. Thrombolytics

12. Mouse models of deep venous thrombosis

13. Summary

14. References

1. ABSTRACT