[Frontiers in Bioscience S4, 941-952, January 1, 2012]

The role of mTOR signaling in Alzheimer disease

Salvatore Oddo1

1Department of Physiology and the Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio. 7703 Floyd Curl Drive, San Antonio, TX 78229

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. mTOR signaling in AD brains
4. mTOR and Abeta
5. mTOR in learning and memory
6. mTOR and tau
7. mTOR and autophagy
8. Conclusions
9. Acknowledgements
10. References

1. ABSTRACT

The buildup of Abeta and tau is believed to directly cause or contribute to the progressive cognitive deficits characteristic of Alzheimer disease. However, the molecular pathways linking Abeta and tau accumulation to learning and memory deficits remain elusive. There is growing evidence that soluble forms of Abeta and tau can obstruct learning and memory by interfering with several signaling cascades. In this review, I will present data showing that the mammalian target of rapamycin (mTOR) may play a role in Abeta and tau induced neurodegeneration.