[Frontiers in Bioscience, Landmark, 20, 829-837, January 1, 2015]

Changes of cytoskeleton affect T cell biological behaviors

Hui Yang 1, 2 , Ruihua Tang 1, 2 , Jing Li 1, 2 , Ji Li 1, 2 , Yaxiong Liu 1, 2 , Linjie Ye 1, 2 , Dongyan Shao 1, 2 , Mingliang Jin 1, 2 , Qingsheng Huang 1, 2 , Junling Shi 1, 2

1School of Life Sciences, Northwestern Polytechnical University, 710072 Xi’an, China, 2Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, 710072 Xi’an, China

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Cytoskeleton interaction in uropod formation of T cell
4. Actin cytoskeleton changes in T cell biological behaviors
    4.1. CXCL12/SDF-1alpha in actin cytoskeleton changes of T cell
    4.2. TCR in actin cytoskeleton changes of T cell
    4.3. Rho family in actin cytoskeleton changes of T cell
    4.4. PI3K in actin cytoskeleton changes of T cell
5. F-actin cytoskeleton
6. Conclusions
7. Acknowledgements
8. References

1. ABSTRACT

T lymphocyte (T cell) is a crucial member in adaptive immunity that protects the organism against foreign pathogens and cancer by producing cytokines and cytotoxic molecules. In T cell, the cytoskeleton is in a stable and dynamic renewed condition and maintains shape and mechanical resistance to deformation. The cytoskeleton changes lead to morphological differences of T cell, and then affect local mechanical properties and cellular behavior, including development, differentiation, polarization, migration or adhesion. In this review, we will discuss the effect of cytoskeleton changes on T cell biological behaviors and its mechanism.

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Abbreviations: ICAMs, intercellular adhesion molecules; LFA-1, lymphocyte function associated antigen 1; SDF-1, stromal cell-derived factor 1; TSAd, T cell specific adapter protein; TCR, T cell receptor; PI3K: phosphatidylinositol-3 kinase; ERM, ezrin–radixin–moesin

Key Words: Cytoskeleton, ICAMs, LFA-1, PI3K, Review

Send correspondence to: Hui Yang, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, China, Tel: 86-29-88460663, Fax:86-29-88460663, E-mail: kittyyh@sina.cn