[Frontiers in Bioscience, Landmark, 20, 1017-1028, June 1, 2015]

Critical role of miRNAs in pancreatic cancer

Bingyan Liu 1 , Xiaoping Zhang 2 , Aiwu Mao 1

1Department of Interventional Radiology, Tongren Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200050, PR China, 2Institute of Medical Intervention Engineering, Tongji University, North Zhongshan Road, Shanghai 200072, PR China

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Epidemiology of pancreatic cancer
4. The characteristics of miRNAs
5. Aberrant Expression of miRNA in PC
6. Function of miRNAs in PC
    6.1. miRNAs modulate proliferation or apoptosis of PC cells
    6.2. miRNAs regulate migration and invasion of PC cells
      6.2.1. miRNAs act as inhibitors of PC cell migration and invasion
      6.2.2. miRNAs act as promoters of PC cell migration and invasion
    6.3. miRNAs affect PC cell sensitivity to radiotherapy or chemotherapy
7. miRNAs as diagnostic markers for pancreatic cancer
8. miRNAs as prognostic and predictive markers of pancreatic cancer
9. Conclusion
10. Acknowledgement
11. Reference

1. ABSTRACT

Pancreatic cancer (PC) is an aggressive malignancy with a high mortality rate and poor prognosis. Numerous investigations have shown that microRNA (miRNA) plays a vital role in PC. Thousands of miRNAs have been screened in PC and altered miRNAs, including circulating miRNAs, are associated with PC proliferation, apoptosis, metastasis, chemosensitivity, and radiosensitivity. Several studies have shown that miRNAs can act as potential diagnostic and prognostic markers. The present review focuses on recent advances regarding the roles of miRNAs in PC and their practical value.

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Abbreviations: 3′UTR, 3′untranslated region; BAX, BCL2-associated X protein; BCL, B-cell lymphoma; CD, cluster of differentiation; KRAS, kirsten rat sarcoma viral oncogene; miRNA, microRNA; PC, pancreatic cancer; PDAC, pancreatic ductal adenocarcinoma; pre-miRNA, precursor miRNA; pri-miRNAs, primary miRNAs; PTEN, phosphatase and tensin homologue 2; PUMA, p53 upregulated modulator of apoptosis; RISC, RNA-induced silencing complex; SHC1, homology 2 domain containing 1; Spry, sprouty homolog; TPM1, tropomyosin 1; TIMP3, tissue inhibitor of metalloproteinase 3

Key Words: Pancreatic Cancer; miRNA, Clinical Application, Review

Send correspondence to: Aiwu Mao, Department of Interventional Radiology, Tongren Hospital, Shanghai Jiaotong University School of Medicine786 Yuyuan Road, Shanghai 200050, P. R. China, Tel: 86-1370114247, Fax: 86-021-62524259, E-mail: maoaiwu@yeah.net