[Frontiers In Bioscience, Elite, 10, 344-351, March 1, 2018]

Modifying progression of aging and reducing the risk of neurodegenerative diseases by probiotics and synbiotics

Huey Shi Lye1, Yee Teng Lee2, Shao Yin Ooi1, Lai Kuan Teh3, Lay Ngor Lim3, Loo Keat Wei2

1Department of Agricultural and Food Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900, Kampar, Perak, Malaysia, 2Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900, Kampar, Perak, Malaysia, 3Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900, Kampar, Perak, Malaysia


1. Abstract
2. Introduction
3. Aging in relation to neurodegenerative diseases
4. Microbiome, one carbon metabolism and aging
5. Neurodegenerative diseases and synbiotic effect
5.1. Probiotics can change the manifestation of diseases
5.2. Synbiotic
6. Summary and prospective
7. Acknowledgement
8. References


Aging, which affects most of the multi-cellular organisms, is due to a potentially complex set of mechanisms that collectively cause a time-dependent decline of physiological functions. Aging restrains longevity and leads to neurodegenerative diseases including dementia, Alzheimer’s disease and lacunar stroke. Human microbiota is now considered to have a strong impact on the progression of aging. The impact of aging and the risk of neurodegenerative diseases can be reduced by using probiotics, or preferably by combining probiotics and prebiotics, also known as synbiotics, that can drastically modify the composition of gut microbiome.


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Abbreviations: SASP: Senescence-Associated Secretory Phenotype

Key Words: Microbiome, Probiotics, Aging, Dementia, Alzheimer’s Disease, Lacunar Stroke, Homocysteine, Synbiotics, Review

Send correspondence to: Loo Keat Wei, Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900, Kampar, Perak, Malaysia, Tel: +605-4688888, Fax: +605-4671676, E-mail: wynnelkw@gmail.com