[Frontiers In Bioscience, Landmark, 24, 1071-1084, March 1, 2019]

Regulation of animal behavior by epigenetic regulators

Kouhei Shimaji1, Saki Tomida2, Masamitsu Yamaguchi2

1Department of Biological Chemistry, University of California, Irvine, 260 Aldrich Hall, Irvine, California, USA, 2Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, Japan

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Learning and memory
3.1. Studies with mammals
3.2. Studies with Drosophila
4. Mating and courtship
4.1. Studies with mammals
4.2. Studies with Drosophila
5. Circadian behavior
5.1. Studies with mammals
5.2. Studies with Drosophila
6. Foraging/starvation-induced hyperactivity
7. Perspectives
8. Acknowledgments
9. References

1. ABSTRACT

Epigenetic regulation in animals induces rapid and long-lasting effects on gene expression in response to environmental changes that frequently affect animal behavior. In the last decade, accumulating studies have revealed how epigenetic regulation affects the behavior of animals, such as learning and memory, mating and courtship, the circadian sleep-wake cycle, and foraging/starvation-induced hyperactivity. In each section of this review, we discuss what we have learned from studies with mammals, mostly mouse models. We then highlight studies with Drosophila models to compare data with mouse models. Finally, we discuss several unanswered questions and future developments in this field.

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DOI: 10.1038/s41398-018-0243-2

Key Words: Review, Epigenetics, Animal behavior, Drosophila melanogaster, Mammals, Learning, Foraging, Mating, Circadian rhythm

Send correspondence to: Masamitsu Yamaguchi, Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan, Tel:  81-75-724-7781, Fax: 81-75-724-7799, E-mail: myamaguc@kit.ac.jp