[Frontiers in Bioscience, Elite, 12, 113-125, Jan 1, 2020]

Predictive value of coronary artery calcium score in cardiovascular disease

Shurong Liu1, Xue Zheng1, Jiahuan Xu4, Xinhua Wang4,Yuzhen Zhang2, Bin Lv3, Liang Zheng2, Kai Sun1,3

1Department of Radiology, Baotou Central Clinical Medicine College, Inner Mongolia Medical University, Inner Mongolia 014040, China, 2Department of Cardiovascular Medicine, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200135,China, 3Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China, 4Baotou Medical Collage, Inner Mongolia 014040, China


1. Abstract
2. Introduction
3. Methods
    3.1. Search strategy
    3.2. Inclusion and exclusion criteria
    3.3. Subjects
    3.4. Assessment scale
    3.5. Search results
    3.6. Study quality
    3.7. Statistical methods
4. Results
    4.1. Baseline characteristics of the participants
    4.2. Quality assessment
5. Discussion
6. Acknowledgments
7. References


We investigated coronary heart disease (CHD) and cardiovascular disease (CVD) event rates in a diverse population with a coronary artery calcium score (CACS) of 0 and the role of CACS in the detection of subclinical noncalcified atherosclerotic plaque. A total of 15,884 participants in five studies were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated. The results showed that CHD incidence significantly increased with increased CACS (HR=0.05, 95% CI 0.03–0.06, Z=5.82, P=0.002). The CHD rate was low and further increased with CACS of 101–300. With CACS >300, the CHD rate was highest. Similarly, CVD rate was low with CACS of 0, increased with CACS of 1–100 (HR=0.03, 95% CI 0.01–0.06, Z=1.66, P=0.096), and further increased with CACS of 101–300. With CACS >300, the CVD rate was highest. Clinical evidence indicated that the higher the CACS, the higher the CHD and CVD rates, while the CVD rate does not always decreased compared with CHD rate with the same CACS, especially with CACS of 0.


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Abbreviations: CHD: coronary heart disease; CVD: cardiovascular disease; cardiovascular disease: coronary artery calcium score; HRs: Hazard ratios; CT: Computed tomography, CCTA: Coronary CT angiography, Review

Key Words :Computed tomography, CT, Coronary artery calcium score, CACS, Coronary heart disease, CHD, Cardiovascular disease, CVD

Send correspondence to: Kai Sun, Department of Radiology, Baotou Central Clinical Medicine College, Inner Mongolia Medical University, Inner Mongolia 014040, China, Tel: 86-018804723588, Fax: 86-2164085875, E-mail: Henrysk@163.com