TUMOR CLASSIFICATION

FRONTIERS IN BIOSCIENCE;

DATA FORM FOR CANCER CLASSIFICATION - BREAST

HISTOPATHOLOGIC TYPE

HISTOPATHOLOGIC GRADE

FEATURE	SCORE	GRADE
Tubule formation (extent within a tumor)
	>%75	1
	10-75%	2
	<10%	3
Nuclear pleomorphism
	Small regular uniform	1
	Moderate variation in shape and size	2
	Marked variation in shape and size	3
Mitotic count per 10 hpf (dependent on microscopic field area)
Field diameter 0.59 mm/area 0.274 mm²
	0-9	1
	10-19	2
	>20	3
Field diameter 0.44 mm/area 0.152 mm²
	0-5	1
	6-10	2
	>11	3
		Final grade

*PROGNOSTIC CLASSIFICATION OF IN SITU* DUCT CELL CARCINOMA OF BREAST**
DIAGNOSIS	NUCLEAR GRADE	CHROMATIN PATTERN	NUCLEOLI	NECROSIS
DCIS, Non-high grade (grade I)	Size 1-1.5 times the size of the RBC (Nuclear grade I)	Diffuse	Inapparent	Absent
DCIS, Non-high grade, (grade II)	Size 1-2 times the size of the RBC (Nuclear grade II)	Coarse	Infrequent	May be present
DCIS, High grade (grade III)	> 2 times the size of the RBC (Nuclear grade III)	Vesicular	One or more	Present (amount not taken into account)
Reference: Silverstein MJ, Poller DN, Waisman JR, Colburn WJ, Barth A, Gierson ED, Lewinsky B, Gamagami P, Slamon DJ: Prognostic classification of breast ductal carcinoma-in-situ. Lancet 1995 May 6;345(8958):1154-1157 MID: 7723550, UI: 95240303

HISTOPATHOLOGIC TYPE		HISTOPATHOLOGIC GRADE
	Carcinoma, NOS
	With comedo feature
	With cribroform feature
	Ductal carcinoma with predominant intraductal component
	Medullary carcinoma with lymphocytic infilatrate
	Lobular carcinoma In situ
	Lobular carcinoma, invasive
	Mucinous (colloid) adenocarcinoma
	Padget's disease, NOS
	Padget's disease with intraductal carcinoma
	Padget's disease with invasive ductal carcinoma
	Papillary carcinoma
	Tubular carcinoma
	Undifferentiated carcinoma

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