7% of the invasive cancers in women.
Peak incidence at 55-65 years of age.
Increased risk is seen with obesity, infertility, hypertension, diabetes mellitus, and prolonged estrogen stimulation.
Clinically manifests as endometrial bleeding or may be discovered as a mass protruding from the endocervix during physical exam.
Grossly appears as a polypoid lesion or as a tumor that broadly infiltrate the endometrium.
Microscopically, the well differentiated tumors appear as glands with the morphologic feature of normal endometrial glands. The glands are densely packed with little intervening stroma or may exhibit a cribriform appearance. The poorly differentiated tumors appear as sheets and rarely form glandular structures. Some tumors may form papillary structures, or may consist of clear cells.