TUMOR GENE DATABASE
Locus: MEL
Subject: Tumor Gene Type
 | Proto-oncogene REFERENCE: Padua-R-A. Barrass-N. Currie-G-A. Nature 311: 671-673 (1984)
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Locus: merlin
Subject: Identification
| Genetic Linkage |
Subject: Tumor Gene Type
| Tumor Supressor Gene |
Locus: met
Subject: Chromosome, Human
| Linked to cystic fibrosis gene. REFERENCE: Unreferenced
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Subject: Tumor Gene Type
| Proto-oncogene |
Locus: MOS
Subject: Signaling Pathway
| Common oncogene transduction paths Revertants of fos transformed cells were resistant to retransformation by v-gag-fos-fox, v-Ha-ras, v-abl, and v-mos but sensitive to retransformation by trk and Polyoma Middle T. This revertant phenotype is recessive. REFERENCE: |
Subject: Tumor Gene Type
| Proto-oncogene |
Locus: myb
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Tsichlis, P. Personal Communication (1991)
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Locus: MYC
Subject: Identification
| Proto-oncogene Avian Myelocytomatosis Virus (AMV). REFERENCE: |
Subject: Phenotype
| Does not block myogenesis Effects of introduction of various oncogenes into myoblasts on their differentiation was studied. myc did not block differentiation. REFERENCE: |
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Roussel-M. Saule-S. Lagrou-C. Rommens-C. Beug-H. Graf-T. Stehelin-D. Nature 281: 452-455 (1979)
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| Proto-oncogene REFERENCE: Unreferenced
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Locus: BMYC
Subject: Tumor Gene Type
| Oncogene Family Member Transcription factor (c-myc homologue). REFERENCE: Asker-C. Steinitz-M. Andersson-K. Sumegi-J. Klein-G. Ingvarsson-S. Oncogene 4: 1523-1527 (1989)
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Locus: LMYC
Subject: DNA Structure
| Structure of 2 human genes A functional gene and a pseudogene. REFERENCE: DePinho-R-A. Hatton-K-S. Tesfaye-A. Yancopoulos-G-D. Alt-F-W. Genes-Dev 1: 1311-1326 (1987)
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Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: NMYC
Subject: Review
| Use of oncogene markers in diagnosis REFERENCE: |
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus:
Subject: Tumor Gene Type
| Oncogene Family Member A member of the c-myc family by sequence similarity. REFERENCE: Burck, K.B., Liu, E.T., and Larrick, J.W. Springer-Verlag-New-York (book): (1988)
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Locus:
Subject: Tumor Gene Type
| Oncogene Family Member A member of the c-myc family, based on sequence similarity. |
Locus: ERBB2
Subject: Clinical
| Gene copy # > 2 => decreased survival In primary breast cancer patients. |
Subject: Oncogenic Activation
| Gene amplification REFERENCE: Ram TG. Dilts CA. Dziubinski ML. Pierce LJ. Ethier SP. Mol Carcinog 15: 227-238 (1996)
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Subject: Review
| Use of oncogene markers in diagnosis REFERENCE: |
Subject: Tumor Gene Type
| proto-oncogene |
| Proto-oncogene REFERENCE: Unreferenced
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Locus: NM23
Subject: Other
| Human gene has 2 forms: Nme1 & Nme2 |
Subject: Tumor Gene Type
| Metastasis-suppressor gene Secondary |
Locus: NRAS
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TP53
Subject: DNA Binding
| p53-induced genes (PIG's) REFERENCE: Polyak K. Xia Y. Zweier JL. Kinzler KW. Vogelstein B. Nature 389: 300-305 (1997)
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| IGF-BP3 gene. IGF-BP3 is the insulin-like growth factor binding protein-3. REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| Bax gene Bax is a member of the BCL2 family that promotes apoptosis. REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| Cyclin G gene REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| GADD45 gene. REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| mdm2 gene REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| mdm2 gene, downstream of exon 1 REFERENCE: Juven T. Barak Y. Zauberman A. George DL. Oren M. Oncogene 8: 3411-3416 (1993)
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Subject: DNA Structure
| Gene size = 16-20 kb REFERENCE: Chang F. Syrjanen S. Tervahauta A. Syrjanen K. Br J Cancer 68: 653-661 (1993)
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Subject: Function
| Transcriptional induction of redox-related PIG genes PIG (p53-Induced Genes) include PIG3, a quinone oxidoreductase homologue; and PIG6, a proline oxidase homologue. REFERENCE: Polyak K. Xia Y. Zweier JL. Kinzler KW. Vogelstein B. Nature 389: 300-305 (1997)
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| Activates transcription of gene encoding IGF-BP3 IGF-BP3 is the insulin-like growth factor binding protein-3. It blocks signaling of a mitogenic growth factor. REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| Activates transcription of GADD45 gene REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| Transcriptionally activates mdm2 gene REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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| Represses TR2 gene expression Fact pertains to MCF-7 cells subjected to ionizing irradiation. TR2 = TR2 orphan receptor, a member of the steroid receptor superfamily REFERENCE: |
Subject: Gene Frequency (Tumors)
| 31% of oral carcinomas (gene mutations) REFERENCE: Matsumura T. Yoshihama Y. Kimura T. Shintani S. Alcalde RE. Oncology 53: 308-312 (1996)
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Subject: Methodology
| Gene status in fine needle aspirates A PCR-based method REFERENCE: Howes GP. Stephenson J. Humphreys S. J Clin Pathol 49: 570-573 (1996)
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Subject: Other
| Gene therapy with 172Arg->Leu mutant This p53 mutant stimulates apoptosis and reduces tumorigenesis in transgenic mice. REFERENCE: Li B. Kittrell FS. Medina D. Rosen JM. Mol Carcinog 14: 75-83 (1995)
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| Gene therapy reduces breast cancer & metastasis In nude mice with breast cancer injected with liposome-p53 complex. REFERENCE: Lesoon-Wood LA. Kim WH. Kleinman HK. Weintraub BD. Mixson AJ. Hum Gene Ther 6: 395-405 (1995)
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Subject: Protein Size
| 393 amino acids for human gene REFERENCE: Levine, A.J. Cell 88: 323-331 (1997)
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Subject: Regulation
| Upregulation without gene mutation in LFS family. LFS = Li-Fraumeni syndrome. This is the first example of a Li-Fraumeni family in which upregulation of p53 expression is not due to a germline mutation in p53 gene. |
Subject: Review
| Genes involved in colorectal tumors REFERENCE: |
Subject: Tumor Gene Type
| Tumor suppressor gene |
| Anti-oncogene REFERENCE: Finlay-C-A. Hinds-P-W. Levine-A-J. Cell 57: 1083-1093 (1989)
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| Anti-oncogene |
Locus: p73
Subject: Function
| When overproduced, can activate p53-responsive genes. SAOS2 cells. REFERENCE: |
Locus: pbx1
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: PDGFR
Subject: Other
| Closely genetically linked to fms The close genetic linkage of FMS (the CSF-1 receptor) and the PDGF receptor, along with their sequence similarity, is taken as suggestion for gene duplication. REFERENCE: Roberts-W-M. Look-A-T. Roussel-M-F. Sherr-C-J. Cell 55: 655-661 (1988)
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Locus: pdgfra
Subject: Tumor Gene Type
| Oncogene Family Member Tyrosine Kinase Receptor. REFERENCE: Unreferenced
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Locus: pdgfrb
Subject: Tumor Gene Type
| Oncogene Family Member Receptor Tyrosine Kinase. REFERENCE: Unreferenced
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Locus: pim1
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: pinF1
Subject: Tumor Gene Type
| Bacterial Oncogene REFERENCE: Unreferenced
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Locus: pinF2
Subject: Tumor Gene Type
| Bacterial Oncogene REFERENCE: Unreferenced
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Locus: pkC gamma
Subject: Oncogenicity
| Not required for FGF-induced mitogenesis A mutant FGF receptor which is unable to activate PLC gamma retains its ability to induce mitogenesis. |
Subject: Signaling Pathway
| PLC not required for mitogenesis It is unclear which of two FGF receptors were used in this work - BEK or FLG. |
Locus: PML
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: PRL
Subject: Function
| Genes affected REFERENCE: Yu-Lee-L-Y. Stevens-A-M. Hrachovy-J-A. Schwarz-L-A. Ann-N-Y-Acad-Sci 594: 146-155 (1990)
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Locus: Polyoma Middle T
Subject: Signaling Pathway
| Common oncogene transduction paths Revertants of fos transformed cells were resistant to retransformation by v-gag-fos-fox, v-Ha-ras, v-abl, and v-mos but sensitive to retransformation by trk and Polyoma Middle T. This revertant phenotype is recessive. REFERENCE: |
Locus: rab4
Subject: Review
| Of ras family of genes REFERENCE: Drivas-G-T. Shih-A. Coutavas-E. Rush-M-G. DEustachio-P. Mol-Cell-Biol 10: 1793-1798 (1990)
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Locus: RAF
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: rar
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: Ras family; H-, K-, & N-
Subject: Phenotype
| Blocks myogenesis Effects of introduction of various oncogenes into myoblasts on their differentiation was studied. ras blocked differentiation. REFERENCE: |
Locus: RB1
Subject: Homologue
| Human gene complements mouse homolog Human RB rescues inviablity in deficient mice. REFERENCE: Bignon YJ. Chen Y. Chang CY. Riley DJ. Windle JJ. Mellon PL. Lee WH. Genes Dev 7: 1654-1662 (1993)
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| Human gene rescues defects of -/- mice Transfer of the human Rb gene into -/- mice corrects their developmental defects. REFERENCE: Lee EY. Chang CY. Hu N. Wang YC. Lai CC. Herrup K. Lee WH. Bradley A. Nature 359: 288-294 (1992)
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Subject: Oncogenicity
| Transgene rescues malignant phenotype Transfecting malignant mouse mammary cells (Rb-) with the murine Rb gene, results in reduced growth rate and delayed onset of tumors. REFERENCE: Hanania EG. Au WW. Ullrich RL. Papaconstantinou J. Cancer Gene Ther 2: 251-261 (1995)
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| Transgene repress colony-forming ability Of MDAMB468 human breast carcinoma cells. REFERENCE: Chen D. Li D. Huang Q. Li A. Gu J. Luo C. Chung Hua Yen Ko Tsa Chih 31: 87-97 (1995)
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| Transgene reduces growth rate by 50% Of MDAMB468 human breast carcinoma cells. (This is a weak evidence for oncogenecity). REFERENCE: Chen D. Li D. Huang Q. Li A. Gu J. Luo C. Chung Hua Yen Ko Tsa Chih 31: 87-97 (1995)
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| Transgene represses cell tumorigenecity Transfection of MDAMB468 human breast carcinoma cells with the Rb gene partially represses tumorigenecity in nude mice. REFERENCE: Chen D. Li D. Huang Q. Li A. Gu J. Luo C. Chung Hua Yen Ko Tsa Chih 31: 87-97 (1995)
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| Transgene suppresses tumorigenicity In nude mice with inactivated RB genes. REFERENCE: Bignon YJ. Chen Y. Chang CY. Riley DJ. Windle JJ. Mellon PL. Lee WH. Genes Dev 7: 1654-1662 (1993)
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Subject: Tumor Gene Type
| Anti-oncogene REFERENCE: Unreferenced
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Locus: RD
Subject: Tumor Gene Type
| Anti-oncogene REFERENCE: Unreferenced
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Locus: rebB
Subject: Oncogenicity
| Genetic Loss correlates with propensity to develop melanoma REFERENCE: Zechel-C. Schleenbecker-U. Anders-A. Anders-F. Oncogene 3: 605-617 (1988)
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Locus: REL
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Chen-I-S. Wilhelmsen-K-C. Temin-H-M. J-Virol 45: 104-113 (1983)
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Locus: RET
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: RIG
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: ROS
Subject: Regulation
| During embryogenesis REFERENCE: Tessarollo-L. Nagarajan-L. Parada-L-F. Development 115: 11-20 (1992)
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Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: Rsr1
Subject: Identification
| Genetic & homology to ras REFERENCE: Bender-A. Pringle-J-R. Proc-Natl-Acad-Sci-U-S-A 86: 9976-9980 (1989)
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Locus: SEA
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: SIS
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: SKI
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: spi1
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: |
Locus: SRC
Subject: Phenotype
| Blocks myogenesis Effects of introduction of various oncogenes into myoblasts on their differentiation was studied. src blocked differentiation. REFERENCE: |
Subject: Review
| General |
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TAL
Subject: Tumor Gene Type
| Proto-oncogene |
Locus: tcl1
Subject: Tumor Gene Type
| Proto-oncogene |
Locus: TCL2
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: tcl5
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TCRA
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TCRB
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Fulton-R. Forrest-D. McFarlane-R. Onions-D. Neil-J-C. Nature 326: 190-194 (1987)
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Locus: TGFbeta
Subject: Function
| On gene expression Blocks expression of dihydropyridine receptor. REFERENCE: Rampe-D. Caffrey-J-M. Schneider-M-D. Brown-A-M. Biochem-Biophys-Res-Commun 152: 769-775 (1988)
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Locus: thy1
Subject: Tumor Gene Type
| Proto-oncogene Effect in transgenic mice. REFERENCE: Kollias-G. Evans-D-J. Ritter-M. Beech-J. Morris-R. Grosveld-F. Cell 51: 21-31 (1987)
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| Proto-oncogene Effect in transgenic mice. REFERENCE: Chen-S. Botteri-F. van-der-Putten-H. Landel-C-P. Evans-G-A. Cell 51: 7-19 (1987)
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Locus: Tlim
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Lane-M-A. Sainten-A. Doherty-K-M. Cooper-G-M. Proc-Natl-Acad-Sci-U-S-A 81: 2227-2231 (1984)
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| Proto-oncogene REFERENCE: |
Locus:
Subject: Cooperation
| With an unknown gene Mutations in the as-yet unidentified cooperating gene results in sarcoma or premenopausal breast cancer. The cooperating gene is not MDM2, BRCA1, or RB1. |
Locus: Tpl1
Subject: Tumor Gene Type
| Proto-oncogene |
Locus: tpl2
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Tsichlis, P. Personal Communication (1991)
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Locus: tpr
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TRK
Subject: Oncogenic Activation
| In vitro gene fusion |
Subject: Signaling Pathway
| Common oncogene transduction paths Revertants of fos transformed cells were resistant to retransformation by v-gag-fos-fox, v-Ha-ras, v-abl, and v-mos but sensitive to retransformation by trk and Polyoma Middle T. This revertant phenotype is recessive. REFERENCE: |
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: TSG101
Subject: Methodology
| Homozygous knockout of recessive genes This strategy which led to the isolation of the novel TSG101 gene, depends on the expression of a selectable marker (in 3T3 mouse fibroblasts) on a vector inserted downstream of promoters of randomly targeted chromosomal gene. Transactivation of a promoter on the noncoding strand of the vector leads to the expression of antisense RNA complementary to the coding strand of the targeted allele, resulting in functional inactivation of the other allele. REFERENCE: |
Locus: TTG1
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: Urokinase
Subject: Function
| Induces c-fos gene expression In human ovarian cancer cells. REFERENCE: Dumler I. Petri T. Schleuning WD. FEBS Lett 343: 103-106 (1994)
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Subject: Regulation
| Activated by the Tpr-Met oncogene Tpr-Met is a constitutively active form of the hepatocyte growth factor/scatter factor receptor Met that is linked to the nuclear envelope protein Tpr. |
| Upregulated by v-mos oncogene Through a MAPKK-dependent signaling pathway. REFERENCE: Lengye E. Singh B. Gum R. Nerlov C. Sabichi A. Birrer M. Boyd D. Oncogene 11: 2639-2648 (1995)
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| Upregulated by tyrosine kinase oncogenes Examples include v-src, v-ras, v-yes and v-ros. REFERENCE: Bell SM. Connolly DC. Maihle NJ. Degen JL. Mol Cell Biol 13: 5888-5897 (1993)
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Locus: VHL
Subject: Identification
| Genetic mapping |
Subject: Tumor Gene Type
| Tumor Supressor Gene |
Locus: WNT
Subject: Review
| The wnt genes |
Locus: WNT-1
Subject: Function
| Genetic Effect Wnt-1 = the mouse "sw" mutation REFERENCE: Thomas-K-R. Musci-T-S. Neumann-P-E. Capecchi-M-R. Cell 67: 969-76. (1991)
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Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: Unreferenced
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Locus: wt1
Subject: DNA Structure
| Identification of gene |
Subject: Function
| Genetic Effect. Denys-Drash syndrome is caused by a mutation in wt1. |
Subject: Tumor Gene Type
| Anti-oncogene REFERENCE: Unreferenced
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Locus: YES
Subject: Tumor Gene Type
| Proto-oncogene REFERENCE: |
Locus: {fake}
Subject: Identification
| Inappropriate - not an oncogene Apparent hybridization to c-myc due to GC rich regions. REFERENCE: Madhavan-K. Bilodeau-Wentworth-D. Wadsworth-S-C. Mol-Cell-Biol 5: 7-16 (1985)
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| Inappropriate - not an oncogene Apparent hybridization to c-myc due to GC rich regions. REFERENCE: Rasmussen-R-D. Staprans-S-I. Shaw-S-B. Spector-D-H. Mol-Cell-Biol 5: 1525-1530 (1985)
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Locus: Oncogenes
Subject: Methodology
| PCR/HPIEX identifies gene copy # PCR = polymerase chain reaction. HPIEX = high performance ion exchange liquid chromatography. REFERENCE: Schmitt JF. Susil BJ. Hearn MT. Growth Factors 13: 19-35 (1996)
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| Genestein inhibits histidine kinase Genestein is used as a specific inhibitor of tyrosine kinases. Here it is shown that genestein also inhibits histidine kinase, so that affects attributed to tyrosine kinases based on genestein sensitivity might actually be due to histidine kinase. REFERENCE: Huang-J. Nasr-M. Kim-Y. Matthews-H-R. J-Biol-Chem 267: 15511-5 (1992)
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Subject: Other
| Cytogenetic analysis Correlation of cytogenetics with radiation dose in leukemias occurring in atomic bomb survivors. REFERENCE: Kamada-N. Tanaka-K. Oguma-N. Mabuchi-K. J-Radiat-Res (Tokyo) 32 Suppl 2: 257-65 (1991)
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Subject: Review
| Cellcycle Checkpt & Genetic Instability REFERENCE: |
| Oncogene regulation in cardiac cells Effects of mechanical stress on cardiac cells: changes in gene expression. REFERENCE: Schneider-M-D. Roberts-R. Parker-T-G. Mol-Biol-Med 8: 167-183 (1991)
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| General REFERENCE: |
| Oncogenes and antioncogenes REFERENCE: |
| Role of oncogenes in signal transduction REFERENCE: |
| Oncogenes in cardiovascular disease REFERENCE: Mulvagh-S-L. Roberts-R. Schneider-M-D. J-Mol-Cell-Cardiol 20: 657-662 (1988)
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| Mouse mammary tumorigenesis REFERENCE: |
Locus: Breast Cancer Oncogene(s)
Subject: Tumor Gene Type
| Tumor Supressor Gene REFERENCE: Ali-I-U. Lidereau-R. Theillet-C. Callahan-R. Science 238: 185-188 (1987)
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