Blood cell count
Elevated serum alkaline phosphatase level
Elevated serum lactate dehydrogenase level
Radiography of bone (bone productive & destructive changes, destruction of cortex, invasion of soft tissues, long thin spicules radiating perpendicularly from a central point " sunburst - pattern ", and elevation of periosteum)
Isotope scanning
Needle biopsy
C.T. scan
Angiography
Chest X ray for the detection of pulmonary metastases