Anemia
Elevated serum level of prostate specific antigen (PSA)
Elevated serum level of prostatic acid phosphatase
Elevated serum level of blood urea nitrogen (BUN)
Enzymatic acid phosphatase assay
Transrectal ultrasound (TRUS) revealing typical hypoechoic peripheral zone lesions
Intravenous urogram may show ureteral obstruction
Chest X ray for the detection of pulmonary metastases
Abdominal X ray for the detection of metastases in the lumbosacral spine
C.T. scan of the pelvis to reveal an enlarged prostate and enlarged pelvic & para aortic lymph nodes
Transrectal needle aspiration & cytological studies
Needle biopsy performed transperineally or transrectally