NAME: Mala R. Chinoy, Ph.D., M.B.A.
DEPT: Surgery
ORGANIZATION: Penn State College of Medicine
ADDRESS: C4840, Department of Surgery, H113, 500 University Drive, Hershey Medical Center, Hershey, PA 17033.
TELEPHONE No: 717-531-1018 (0); 717-531-4049 (Lab)
FAX No: 717-531-4185
E MAIL ADDRESS: mchinoy@psu.edu
TITLE: Professor of Surgery, Faculty of Graduate Programs in Genetics and Integrated Biosciences.
TOTAL PUBLICATIONS: 48 peer-reviewed publications; 3 books chapters; 2 educational books for middle school students.
MEMBERSHIPS ON EDITORIAL BOARDS: Frontiers in Bioscience; REVIEWER FOR THE PEER-REVIEWED JOURNALS: American Journal of Physiology (Lung Cellular and Molecular Physiology), Pediatric Pulmonology, Pediatric Research, American Journal of Pathology, Biochemical et Biophysica Acta, International Journal of Cancer, Histology and Histopathology, Journal of Pediatric Surgery, Nature Genetics, Pharmacology, Journal of Applied Physiology, European Respiratory Journal

SUBJECT(S) OF RESEARCH: Cardiopulmonary Developmental Defects
DISCIPLINE(S): Pulmonary Biology
ORGAN SYSTEMS: Respiratory system and Circulatory system
TISSUES: Lung, Heart, Vasculature, Liver, Connective tissue
CELL(S): epithelial cells, fibroblasts, endothelial cells, myocytes, cell cultures, organ cultures, somatic stem cells
MOLECULE(S): Growth factors (TGF-beta, EGF, VEGF, Ang-1, IGF), steroids, retinoids, thyroid hormone, MMPs, TN-C, TTF-1, connexins
TECHNIQUE(S): Cell Biology- Fetal, neonatal and adult - lung developmental study. Mouse, Rat and human in vitro and in vivo systems - primary cells, explants and organ cultures; cell-matrix interactions using variety of substrata; intact lung model. Biochemistry- Surfactant uptake using radioactive double label; effects of secretagogues on surfactant uptake, enzyme assays. Molecular Biology- Recombinant DNA Techniques and Applications; Polymerase Chain Reaction (PCR) Applications; In-situ PCR; Gene expression and regulation; Differential Display of genes; cDNA microarrays; DNA Sequencing; in vitro gene transfer using retroviruses; identification and characterization of proteins by 1D, 2D gels (Western blotting and protein profiles) and protein sequencing. Morphology- Scanning and Transmission Electron Microscopy; Laser Confocal Microscopy; Light Microscopy (LM); Morphometric analysis; Histochemistry; Immunohistochemistry; Cryomicrotomy; Ultra-microtomy; Electron Probe Microanalysis. Embryology- Molecular Embryology of the Mouse. Surgical and other techniques- airway ligations, India Ink injections, vascular casts, intra-gastric gavage, canulations, survival sugeries.