NAME: Sharron H. Francis, Ph.D.
DEPT: Molecular Physiology & Biophysics
ORGANIZATION: Vanderbilt University School of Medicine
ADDRESS: Light Hall Room 702
TELEPHONE No: 615-322-4383
FAX No: 615-343-3794
E MAIL ADDRESS: Sharron.francis@vanderbilt.edu
TITLE: Research Professor
TOTAL GRANTS:
TOTAL PUBLICATIONS: 102
MEMBERSHIPS ON EDITORIAL BOARDS: Frontiers in Bioscience,

SUBJECT(S) OF RESEARCH: cGMP signaling; cGMP-dependent protein kinases; cyclic nucleotide phosphodiesterases; phosphodiesterase inhibitors; smooth muscle relaxation
DISCIPLINE(S): biochemistry, enzymology, physiology
ORGAN SYSTEMS:
TISSUES: vascular smooth muscle; airway smooth muscle
CELL(S): vascular smooth muscle cells
MOLECULE(S): cGMP; sildenafil (Viagra™); tadalafil (Cialis™); vardenafil (Levitra™); zinc
TECHNIQUE(S): recombinant proteins; binding of radiolabeled ligands; site-directed mutagenesis