5-Lipoxygenase

Normal development
Healthy
Normal reaction to endotoxin shock
Normal inflammatory response to phorbol ester
Normal acute inflammatory response induced by arachidonic acid (Goulet et al., 1994)
Selective opposition to certain inflammatory insults
Resistance to the lethal anaphylaxis and shock induced by platelet-activating factor
Reduced inflammatory response to arachidonic acid (Chen et al., 1994)
Inability to synthesize detectable levels of leukotrienes

Chen et al., 1994
Goulet et al., 1994

((5-lipoxygenase))

	Line Name	DNA Construct
1.	5-lipoxygenase (5LX	The targeting vector was constructed in the pCR1000 vector (Invitrogen) from a 6.85-kb SacI-EcoRI 5-lipoxygenase genomic fragment isolated by scree....